Which of the following statements on DNA replication is CORRECT ?
A.
DNA is synthesized by extending the 3′ end of the primer, because the 3′-OH acts as a nucleophile during catalysis
B.
DNA Pol use s four different active sites to recognize the four different dNTPs when it catalyzes DNA synthesis
C.
DNA Pol does not add rNTP to the 3′ end of the growing DNA strand because rNTP concentrations are too low in cells
D.
During DNA replication, the leading strand and lagging strand are synthesized toward opposite directions and cannot be coordinated