Such agents as clavulanic acid, sulbactam, or tazobactam are often added to some proprietary (manufactured) penicillin combination products. Which of the followings is the main reason for including them, or BEST describes their action?
A.
Add antibiotic activity against Pseudomonas and many Enterobacter species
B.
Facilitate antibiotic penetration into the central nervous system and cerebrospinal fluid
C.
Inhibit cell wall transpeptidases
D.
Inhibit inactivation of penicillin by b-lactamase-producing bacteria
E.
Inhibit the normally significant hepatic metabolism of the penicillin