How is Cdk activity blocked by Cdk inhibitor proteins?
A.
In addition to phosphorylation and dephosphorylation, the activity of Cdks can also be modulated by the binding of Cdk inhibitor proteins.
B.
The cell-cycle control system uses these inhibitors to block the assembly or activity of certain cyclin–Cdk complexes.
C.
Some Cdk inhibitor proteins, for example, help maintain Cdks in an inactive state during the G 1 phase of the cycle, thus delaying progression into S phase.
D.
Pausing at this transition point in G 1 gives the cell more time to grow, or allows it to wait until extracellular conditions are favorable for division.