At birth, a full-term male neonate was found to be severely acidotic. His condition was found to result from an X-linked dominant mutation of the α - subunit of E1 in the PDC. Compared with a healthy neonate in the same dietary state, what would be the consequences of this mutation?
A.
An increase in plasma concentrations of lactate and pyruvate
B.
A higher ATP/ADP ratio in cells of the brain
C.
A decrease in the rate of glycolysis in brain cells
D.
An increase in the activity of the electron-transfer chain in brain cells
E.
An increase in plasma acetyl-CoA levels