【单选题】You are creating a tabular report for the sales department with a department break group. You need to ensure that if al least six sales records will not fit at the button of a page, the group will sta...
【单选题】Which of the following statements about glutamate dehydrogenase’s regulation and mutation is wrong?
A.
Glutamate dehydrogenase operates at an important intersection of carbon and nitrogen metabolism.
B.
An allosteric enzyme with 8 identical subunits, its activity is influenced by a complicated array of allosteric modulators.
C.
The best-studied of these are the positive modulator ADP and the negative modulator GTP.
D.
Mutations that alter the allosteric binding site for GTP or otherwise cause permanent activation of glutamate dehydrogenase lead to a human genetic disorder called hyperinsulinism-hyperammonemia syndrome, characterized by elevated levels of ammonia in the bloodstream and hypoglycemia.
【单选题】You are developing an inventory report to list the item number, description price and picture of all inventory items. The layout of each item is a repeating frame that contains three fixed fields and ...
【多选题】How can extracellular signals alter the arrangement of actin filaments?
A.
Actin-binding proteins control the location, organization, and behavior of actin filaments. The activities of these proteins are, in turn, controlled by extracellular signal molecules, allowing the cell to rearrange its actin cytoskeleton in response to its environment.
B.
These extracellular signals act through a variety of cell-surface receptor proteins, which activate various intracellular signaling pathways. Many of these pathways converge on a group of closely related monomeric GTPases that are part of the Rho protein family. Monomeric GTPases behave as molecular switches that control intracellular processes by cycling between an active GTP-bound state and an inactive GDP-bound state.
C.
In the case of the actin cytoskeleton, different Rho family members alter the organization of actin filaments in different ways. For example, one Rho family member triggers the bundling of actin filaments and activation of the formin proteins that promote the formation of filopodia. Another Rho GTPase might stimulate ARP complexes at the cell’s leading edge, promoting the formation of lamellipodia and membrane ruffling.
D.
Finally, activation of the founding member of the Rho family drives the bundling of actin filaments with myosin motor proteins and the clustering of cellsurface integrins, actions that promote cell crawling.