【单选题】, Which of the following statement is wrong regarding the de novo synthesis of purine nucleotides:
A.
IMP is first synthesized, and then branched into synthesis of AMP and GMP.
B.
Substrate ribose-5-phosphate in the salvage pathway of nucleotide synthesis is provided by 5-phosphoribosyl-1-pyrophosphate.
C.
Both of the synthesis of 5-phosphoribosyl-1-pyrophosphate (PRPP) and 5-phosphoribosyl-1 amine (PRA) are regulatory points in the de novo synthesis of purine nucleotides.
D.
The synthesis of 5-phosphoribosyl-1 amine (PRA) is the committed step in the de novo synthesis of purine nucleotides.
E.
It is the least important pathway for purine nucleotide synthesis.