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【多选题】
What is Lesch-Nyhan syndrome ?A.
A genetic lack of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity, seen almost exclusively in young boys, results in a bizarre set of symptoms called Lesch-Nyhan syndrome.
B.
Children with this genetic disorder, which becomes manifest by the age of 2 years, are sometimes poorly coordinated and have intellectual deficits. In addition, they are extremely hostile and show compulsive self-destructive tendencies: they mutilate themselves by biting off their fingers, toes, and lips.
C.
The devastating effects of Lesch-Nyhan syndrome illustrate the importance of the salvage pathways. Hypoxanthine and guanine arise constantly from the breakdown of nucleic acids. In the absence of HGPRT , PRPP levels rise and purines are overproduced by the de novo pathway, resulting in high levels of uric acid production and goutlike damage to tissue.
D.
The brain is especially dependent on the salvage pathways, and this may account for the central nervous system damage in children with Lesch-Nyhan syndrome. This syndrome is another potential target for gene therapy.
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【多选题】20世纪是一个大变革的时代,山西涌现出一大批中国现代文学史上的经典作品,如赵树理的小说()
A.
小二黑结婚》
B.
《大堰河,我的保姆》
C.
《李有才板话》
D.
《日出》
【简答题】v. (使)滑动;(使)滑行 n.滑;滑动;幻灯片_______
【简答题】1滑动, 滑行, 幻灯片 2 皮肤, 外壳 3 残酷的 4满足的, 满意的 5使惊讶 6特殊的, 特别的 7使欢乐; 款待
【简答题】改变; 突然发生;爆裂; 处置;解决; 消耗;耗尽; 滑动;幻灯片; 细菌; 繁殖;产仔; 预算; 慷慨的;自由的; 转变;变革; 移植; 消失; 吞下;燕子; 怀疑; 怀疑的;可疑的; 温柔的;脆弱的; 损害;妨害;
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