【多选题】What are the major concerns with germline gene editing?
A.
Some of the concerns raised about somatic gene transfer are related to the possibility that it could inadvertently lead to germline gene transfer. Germline gene transfer at the te and zygote stages have significant risks.
B.
Beyond the medical risks to the potential child, a number of long-standing ethical concerns exist regarding the possible practice of germline gene transfer in both human and nonhuman cases.
C.
Concerns involve issues ranging from the autonomy of future individuals to distributive justice, fairness, and the application of these technologies to "enhancement". Concerns related to eugenics and social justice and equal access to technologies.
D.
Unequal access and cultural differences affecting uptake could create large differences in the relative incidence of a given condition by region, ethnic group, or socioeconomic status.