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The cellular pools of nucleotides (other than ATP) are quite small, perhaps _____ or less of the amounts required to synthesize the cell’s DNA. Therefore, cells must continue to synthesize nucleotides during nucleic acid synthesis, and in some cases, nucleotide synthesis may limit the rates of DNA replication and transcription. Because of the importance of these processes in dividing cells, agents that inhibit nucleotide synthesis have become particularly important in medicine.