A.
Ethical and social values regarding germline genome editing need to be solicited and considered.
B.
There are three general approaches to addressing the ethical justification and stakeholder assessment of germline genome editing: conducting primary research; conducting secondary analyses of published literature on the perceptions, acceptability, quality of life, attitudes, or values of stakeholders; and commissioning an expert review.
C.
Engaging broader stakeholder groups, including the medical and scientific communities, persons and families dealing with genetically based disabilities, and the general public, would be warranted given the potential uses and impacts of germline genome-editing technology.
D.
These debates and engagements should weigh the risks, benefits, alternatives, unknown consequences, and access, as well as distributive and procedural justice, both on a societal level (across and within societies) and on an individual or community basis. Ultimately, these debates and engagements will inform the frameworks to enable ethical uses of the technology while prohibiting unethical ones.