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【单选题】
患者慢性肾炎5年，近来出现衰弱无力、尿少，水肿较前加重，并有轻度贫血，血压160/100mmHg。下列检查中最先出现异常的是（）A.
尿浓缩试验
B.
酚红排泌试验
C.
肌酐清除率
D.
血尿素氮浓度
E.
血肌酐浓度
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