A.
Two decades after the initial gene therapy trials and more than 2,000 approved clinical trials worldwide we not only have gained much new information and knowledge regarding gene therapy in general, but also learned to understand the concern that has persisted in society.
B.
Nevertheless, our knowledge continues to grow and during the course of time more safety data has become available that helps us to develop better gene therapy approaches. Also, with the increased understanding of molecular medicine, we have been able to develop more specific and efficient gene transfer vectors which are now producing clinical results.
C.
Despite the setbacks gene therapy has faced, success stories have increasingly emerged. Without doubt, the ethical aspects regarding gene therapy need to be addressed the same way as the question about their efficacy and safety.
D.
We need to acknowledge the fear of some patients in respect to gene therapy. Ultimately it is the patient who decides, whether she/he wants to be treated with gene therapy.