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【单选题】
一对称臂的洒水喷嘴如图所示，旋转半径R=200mm，每一个喷嘴的射流流量Q=0．56L／s，流速v=5．57m／s，旋转角速ω=10．75rad／s（弧度／秒）。为克服摩擦阻力，保持转速不变，其对转轴需施加的力矩M为（）A.
0.766N·m
B.
0.25N·m
C.
0.3N·m
D.
0.4N·m
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【简答题】基因治疗(gene therapy)
【多选题】The major risks for gene therapy include:
A.
Gene therapy can trigger the immune response in the patient, that could be harmful to them. Retroviruses has raised skepticism about their safety. Deactivated viruses are really deactivated?
B.
Viral vectors may cause toxicity, infection, inflammation, etc.
C.
Gene therapy may cause off-target effects — there is a risk that the new gene will insert itself into the path of another gene, disrupting its activity, or cause insertional mutagenesis.
D.
Gene therapy may cause chronic granulomatous disease and cancer.
【多选题】Which of the following statements on gene therapy are correct?
A.
Two decades after the initial gene therapy trials and more than 2,000 approved clinical trials worldwide we not only have gained much new information and knowledge regarding gene therapy in general, but also learned to understand the concern that has persisted in society.
B.
Nevertheless, our knowledge continues to grow and during the course of time more safety data has become available that helps us to develop better gene therapy approaches. Also, with the increased understanding of molecular medicine, we have been able to develop more specific and efficient gene transfer vectors which are now producing clinical results.
C.
Despite the setbacks gene therapy has faced, success stories have increasingly emerged. Without doubt, the ethical aspects regarding gene therapy need to be addressed the same way as the question about their efficacy and safety.
D.
We need to acknowledge the fear of some patients in respect to gene therapy. Ultimately it is the patient who decides, whether she/he wants to be treated with gene therapy.
【简答题】Recommendations from "Statement on Gene Therapy Research" initiated by HUGO in 2001 include:A. Recognizes the particular need for public oversight and ongoing review of somatic gene therapy research; ...
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